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Quality products?make an important contribution to long-term revenue and profitability. Chemical plants supply high-quality N-Oleoylethanolamine 111-58-0 in bulk
1.What is the N-Oleoylethanolamine ?
N-Oleoyl Ethanolamide is an agonist of peroxisome proliferator-activated receptor-α (PPAR-α). N-Oleoyl Ethanolamide generates an intestinal signal that stimulates central dopamine activity establishing a link between caloric-homeostatic and hedonic-homeostatic controllers. Oleoyl Ethanolamide has been implicated as the molecular mechanism associated with gastric bypass success. N-Oleoyl Ethanolamide is a selective GPR55 agonist.
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112-80-1,2027-47-6
cis-Octadecenoic acid
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60-33-3,116745-32-5,26085-09-6,64080-88-2,7049-66-3,949900-18-9,60476-23-5,6144-28-1,67922-65-0,89718-18-3
linoleic acid
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141-43-5
ethanolamine
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7545-20-2,111-58-0
N-oleoylethanolamine
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68171-52-8
N-linoleoylethanolamine
| Conditions | Yield |
|---|---|
|
With
sodium methylate;
In
ethanol; hexane;
for 3h;
Solvent;
Concentration;
Time;
|
70.3%
|
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-
112-80-1,2027-47-6
cis-Octadecenoic acid
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-
141-43-5
ethanolamine
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7545-20-2,111-58-0
N-oleoylethanolamine
| Conditions | Yield |
|---|---|
|
With
Candida antarctica lipase; water;
In
hexane;
at 65 ℃;
for 3h;
Time;
Temperature;
Concentration;
|
96.8%
|
|
In
dichloromethane;
at 20 ℃;
for 1h;
Cooling with ice;
|
96%
|
|
cis-Octadecenoic acid;
With
1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; acetonitrile;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
ethanolamine;
In
dichloromethane; acetonitrile;
at 20 ℃;
Inert atmosphere;
|
89%
|
|
With
Novozym 435, consisting of immobilized Candida antarctica lipase B;
In
hexane;
at 40 ℃;
for 6h;
Enzymatic reaction;
|
88%
|
|
cis-Octadecenoic acid;
With
benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
dichloromethane;
for 1h;
ethanolamine;
In
dichloromethane;
for 2h;
|
61%
|
|
at 160 ℃;
under 5 - 10 Torr;
|
|
|
|
|
|
cis-Octadecenoic acid;
With
1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
for 0.166667h;
ethanolamine;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 0.25h;
|
29 mg
|
|
cis-Octadecenoic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
ethyl acetate;
at 20 ℃;
for 1h;
ethanolamine;
In
ethyl acetate;
at 20 ℃;
for 12h;
|
|
|
cis-Octadecenoic acid;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.0333333h;
ethanolamine;
With
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;
In
dichloromethane;
at 0 - 20 ℃;
|
|
|
With
zeolite H-beta-22;
In
hexane;
at 120 ℃;
for 3h;
under 15001.5 Torr;
Reagent/catalyst;
Inert atmosphere;
|
|
|
at 90 ℃;
for 1h;
Large scale;
|
2.What is the CAS number for N-Oleoylethanolamine ?
The CAS number of N-Oleoylethanolamine is 111-58-0.
More information of N-Oleoylethanolamine 111-58-0 are:
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CAS?Number |
111-58-0 |
|
Density |
0.915 g/cm3 |
|
Melting Point |
50-60oC |
|
Boiling Point |
496.35 °C at 760 mmHg |
|
Flash Point |
253.984 °C |
|
Vapor Pressure |
6.22E-12mmHg at 25°C |
|
Refractive Index |
1.473 |
|
PSA |
49.33000 |
|
LogP |
5.52330 |
|
Pka |
14.49±0.10(Predicted) |
3.What are another words for N-Oleoylethanolamine ?
Synonyms?for?N-Oleoylethanolamine 111-58-0:9-Octadecenamide,N-(2-hydroxyethyl)-, (Z)-;Oleamide, N-(2-hydroxyethyl)- (6CI,7CI,8CI);AM3101;N-(2-Hydroxyethyl)oleamide;N-Oleoyl-2-aminoethanol;N-Oleoylethanolamine;Oleamide MEA;Oleic acid ethanolamide;Oleic acidmonoethanolamide;Oleoylethanolamide;N-(2-Hydroxyethyl)-9-octadecenamide;
4.What is the molecular formula of N-Oleoylethanolamine?
The chemical formula of ?N-Oleoylethanolamine is?C20 H39 NO2 which containing 20 Carbon atoms,39 Hydrogen atoms,1 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of??N-Oleoylethanolamine?is 325.535.
5.What is N-Oleoylethanolamine (111-58-0) used for?
Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate. It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue, but its biosynthesis is reduced in the intestine of rats following food deprivation. OEA is an endogenous, potent agonist for PPARα, exhibiting an EC50 value of 120 nM in a transactivation assay. Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice. These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.
InChI:InChI=1/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
Relevant articles related to N-Oleoylethanolamine:
|
Article |
Source |
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Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404 |
Giuffrida, Andrea,Rodriguez De Fonseca, Fernando,Nava, Felice,Loubet-Lescoulie, Patrick,Piomelli, Daniele , p. 161 - 168 (2000) |
|
Membrane-stabilizing properties of cis-9-octadecenoic acid N-(2-hydroxyethyl)amide |
Klenova,Belousova , p. 423 - 424 (2002) |
6.Buy N-Oleoylethanolamine with the best price .
Ningbo EST Chemical Co., Ltd is a quality supplier of N-Oleoylethanolamine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on N-Oleoylethanolamine 111-58-0.
