What is the CAS number for Simeprevir?

The CAS number of Simeprevir is 923604-59-5.

What is Simeprevir (923604-59-5) used for?

In September 2013, simeprevir (also known as TMC435) was approved in Japan (trade name Sovriad?) for the treatment of genotype 1 hepatitis C virus (HCV) infection in combination with pegylated interferon and ribavirin (PR). Simeprevir was approved for the same indication in November 2013 in the United States (trade name Olysio?) and Canada (trade name Galexos?). Simeprevir is the third HCV PI to receive approval and was discovered from an effort to optimize a novel series of cyclopentane-core macrocyclic HCV PIs. Unlike the earlier PIs, simeprevir does not rely on formation of a covalent intermediate to inhibit the enzyme, but instead gains binding affinity through a large P2 quinoline substituent that occupies an extended S2 subsite of HCV protease by induced fit. This pocket is not occupied by inhibitors such as telaprevir and boceprevir. Other key features of simeprevir are truncation of the P3 capping group (the N-methyl amide), use of an acylsulfonamide as an acid isostere, and incorporation of an isopropylthiazole group to give improved permeability. Simeprevir is a potent NS3/4A PI (Ki=0.36 nM), with antiviral activity in the HCV replicon assay (genotype 1b EC50=7.8 nM; genotype 1a EC50=28.4 nM). It is 25-fold less potent against HCV genotype 2, >1000 less potent for HCV genotype 3, but has 3-fold better potency for HCV genotype 4.

What is the CAS number for Simeprevir?

The CAS number of Simeprevir is 923604-59-5.

What is Simeprevir (923604-59-5) used for?

In September 2013, simeprevir (also known as TMC435) was approved in Japan (trade name Sovriad?) for the treatment of genotype 1 hepatitis C virus (HCV) infection in combination with pegylated interferon and ribavirin (PR). Simeprevir was approved for the same indication in November 2013 in the United States (trade name Olysio?) and Canada (trade name Galexos?). Simeprevir is the third HCV PI to receive approval and was discovered from an effort to optimize a novel series of cyclopentane-core macrocyclic HCV PIs. Unlike the earlier PIs, simeprevir does not rely on formation of a covalent intermediate to inhibit the enzyme, but instead gains binding affinity through a large P2 quinoline substituent that occupies an extended S2 subsite of HCV protease by induced fit. This pocket is not occupied by inhibitors such as telaprevir and boceprevir. Other key features of simeprevir are truncation of the P3 capping group (the N-methyl amide), use of an acylsulfonamide as an acid isostere, and incorporation of an isopropylthiazole group to give improved permeability. Simeprevir is a potent NS3/4A PI (Ki=0.36 nM), with antiviral activity in the HCV replicon assay (genotype 1b EC50=7.8 nM; genotype 1a EC50=28.4 nM). It is 25-fold less potent against HCV genotype 2, >1000 less potent for HCV genotype 3, but has 3-fold better potency for HCV genotype 4.

China cas 923604-59-5 manufacturer wholesale Simeprevir at affordable price

Q: What is the Simeprevir?

Simeprevir is , while it's Molecular Formula is C 38 H 47 N 5 O 7 S 2 . Used in Pharmaceutical Industry: Simeprevir is used as an antiviral agent for the treatment of genotype 1 hepatitis C virus (HCV) infection. It is administered in combination with pegylated interferon and ribavirin (PR) to enhance the therapeutic efficacy and provide a more effective treatment option for patients suffering from this viral infection.

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Simeprevir

CAS No.: 923604-59-5
Purity: 99%

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China cas 923604-59-5 manufacturer wholesale Simeprevir at affordable price We supply high quality Simeprevir (CAS 923604-59-5), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Simeprevir ?

Simeprevir is , while it's Molecular Formula is C₃₈H₄₇N₅O₇S₂. Used in Pharmaceutical Industry:
Simeprevir is used as an antiviral agent for the treatment of genotype 1 hepatitis C virus (HCV) infection. It is administered in combination with pegylated interferon and ribavirin (PR) to enhance the therapeutic efficacy and provide a more effective treatment option for patients suffering from this viral infection.

How to get the best price on Simeprevir?

Ningbo EST Chemical Co., Ltd is a quality supplier and manufacturer of Simeprevir . You can buy high quality, low price Simeprevir 923604-59-5 here. Contact us.