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What is the Abacavir ?
Abacavir is white powder, while it's Molecular Formula is C14H18N6O. A nucleoside reverse transcriptase inhibitor (NRTI).
What is the CAS number for Abacavir ?
The CAS number of Abacavir is 136470-78-5.
More information of Abacavir 136470-78-5 are:
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Synonyms |
{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol;Ziagen;2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S-cis)-;4-Amino-5-chloro-2-ethoxy benzoic acid;Trizivir;2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-;Abacavir (Ziagen); |
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CAS?Number |
136470-78-5 |
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Molecular Formula |
C14H18N6O |
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Molecular Weight |
286.337 |
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Density |
1.7 g/cm3 |
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Melting Point |
165° |
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Boiling Point |
636 °C at 760 mmHg |
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Flash Point |
338.4 °C |
|
PSA |
101.88000 |
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LogP |
1.74650 |
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Pka |
5.01(at 25℃) |
What is Abacavir (136470-78-5) used for?
The drug is extensively metabolized via stepwise phosphorylation to 5′-mono-, di-, and triphosphate. Abacavir is well absorbed (>75%) and penetrates the CNS. The drug can be taken without regard to meals. The drug does not show any clinically significant drug–drug interactions. Abacavir has been reported to produce life-threatening hypersensitivity reactions. The major use of abacavir appears to be in combination with other nucleoside RT inhibitors. A fixed-combination product has recently been approved by the U.S. FDA consisting of 300 mg of ABC, 150 mg of 3TC, and 300 mg of ZDV (Trizivar). The combination has been shown to be superior to other combinations in reducing viral load as well as to show improvement in CD4 cell count.
InChI:InChI=1/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m0/s1
Articles related to Abacavir:
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Article |
Source |
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Abacavir intermediate and method for purifying same |
- Paragraph 0079-0080, (2018/03/26) |
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PROCESS FOR THE PREPARATION OF AMINO ALCOHOL DERIVATIVES OR SALTS THEREOF |
- Paragraph 0056; 0057; 0058; 0059; 0060, (2017/09/02) |
How to get the best price on Abacavir?
Ningbo EST Chemical Co., Ltd is a quality supplier and manufacturer of Abacavir . You can buy high quality, low price Abacavir 136470-78-5 here. Contact us.
