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High Quality Chinese Factory supply 4547-24-4 Corosolic acid We supply high quality Corosolic acid (CAS 4547-24-4), in stock, factory directly supply to clients, lower prices, more competitiveness.
What is the Corosolic acid ?
Corosolic acid is Fine-Brown Yellow Powder, while it's Molecular Formula is C30 H48 O4 . (2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tum or activity
What is the CAS number for Corosolic acid ?
The CAS number of Corosolic acid is 4547-24-4.
More information of Corosolic acid 4547-24-4 are:
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Synonyms |
Urs-12-en-28-oicacid, 2a,3b-dihydroxy- (7CI,8CI);2a,3b-Dihydroxyurs-12-en-28-oic acid;2a-Hydroxyursolic acid;Colosic acid;Corsolic acid;Glucosol; |
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CAS?Number |
4547-24-4 |
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Molecular Formula |
C30 H48 O4 |
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Molecular Weight |
472.709 |
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Density |
1.14 g/cm3 |
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Melting Point |
243～245℃ |
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Boiling Point |
573.3 °C at 760 mmHg |
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Flash Point |
314.6 °C |
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HS CODE |
2918195000 |
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PSA |
77.76000 |
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LogP |
6.06030 |
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Pka |
4.67±0.70(Predicted) |
What is Corosolic acid (4547-24-4) used for?
Corosolic acid is a triterpenoid that has been found in L. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties. It is cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively). Corosolic acid inhibits ear edema in mice induced by phorbol 12-myristate 13-acetate (TPA; ) with an ID50 value of 0.09 mg/ear. It reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes when administered at doses of 2 and 10 mg/kg. Corosolic acid (0.072% in the diet) reduces systolic blood pressure and serum levels of free fatty acids, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2’-deoxyguanosine (8-OHdG), and the myeloperoxidase markers 3-nitrotyrosine and 3-chlorotyrosine in an SHR/NDmcr-cp (cp/cp) rat model of metabolic syndrome.
InChI:InChI=1/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
Articles related to Corosolic acid:
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Article |
Source |
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Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties |
Nelson, Andrew T.,Camelio, Andrew M.,Claussen, Karin R.,Cho, Jiyoon,Tremmel, Lisa,Digiovanni, John,Siegel, Dionicio , p. 4342 - 4346 (2015/11/03) |
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Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: Synthesis, structure-activity relationships, and X-ray crystallographic studies |
Wen, Xiaoan,Sun, Hongbin,Liu, Jun,Cheng, Keguang,Zhang, Pu,Zhang, Liying,Hao, Jia,Zhang, Luyong,Ni, Peizhou,Zographos, Spyros E.,Leonidas, Demettes D.,Alexacou, Kyra-Melinda,Gimisis, Thanasis,Hayes, Joseph M.,Oikonomakos, Nikos G. experimental part, p. 3540 - 3554 (2009/04/07) |
How to get the best price on Corosolic acid?
Ningbo EST Chemical Co., Ltd is a quality supplier and manufacturer of Corosolic acid . You can buy high quality, low price Corosolic acid 4547-24-4 here. Contact us.
