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2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE
- CAS No.: 230615-52-8
- Purity: 99%
Manufacturer supply good quality 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE 230615-52-8 with stock
- Molecular Formula: C11H13N.HCl
- Molecular Weight: 195.692
- Vapor Pressure: 0.00439mmHg at 25°C
- Boiling Point: 277.9 °C at 760 mmHg
- Flash Point: 128.9 °C
- PSA： 12.03000
- LogP: 2.99150
2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE(Cas 230615-52-8) Usage
InChI:InChI=1/C11H13N.ClH/c1-2-4-11-9-5-8(6-12-7-9)10(11)3-1;/h1-4,8-9,12H,5-7H2;1H
230615-52-8 Relevant articles
Preparation method of varenicline key intermediate
-
Paragraph 0114-0122, (2019/04/04)
The invention discloses a preparation me...
PROCESS FOR PREPARING VARENICLINE, VARENICLINE INTERMEDIATES, AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
-
Page/Page column 16, (2010/04/06)
Provided herein is an improved, convenie...
PROCESSES FOR THE PREPARATION OF VARENICLINE AND INTERMEDIATES THEREOF
-
Page/Page column 9, (2009/12/28)
The invention provides an improved proce...
230615-52-8 Process route
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230615-48-2
3-benzyl-2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine
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-
230615-52-8
2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; hydrogen;
palladium(II) hydroxide;
In
methanol;
at 20 - 40 ℃;
under 3677.86 - 4413.43 Torr;
|
89.24%
|
|
3-benzyl-2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine;
With
ammonium formate;
palladium(II) hydroxide;
In
methanol;
for 0.5h;
Inert atmosphere of nitrogen;
Reflux;
With
hydrogenchloride;
In
ethyl acetate;
at 0 - 5 ℃;
for 1h;
pH=1 - 2;
|
-
![10-Aza-tricyclo[6.3.1.02.7]dodeca-2<sup>(7)</sup>,3,5-triene](/upload/2026/10/b480823896b64ef295b6c118fc1cacae_925392dd-082b-47ae-a722-488e500f9f13.png)
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69718-72-5
10-Aza-tricyclo[6.3.1.02.7]dodeca-2(7) ,3,5-triene
-
-
230615-52-8
2,3,4,5-tetrahydro-1,5-methylene-1H-3-benzazepine hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
methanol;
at 0 - 5 ℃;
Solvent;
|
96%
|
230615-52-8 Upstream products
-
230615-48-2
3-benzyl-2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine
-
615-13-4
2-indanone
-
39094-23-0
1,3-dibromo-indan-2-one
-
69718-72-5
10-Aza-tricyclo[6.3.1.02.7]dodeca-2(7) ,3,5-triene
230615-52-8 Downstream products
-
230615-51-7
1-(10-aza-tricyclo[6.3.1.02,7 ]dodeca-2(7) ,3,5-trien-10-yl)-2,2,2-trifluoro-ethanone
-
230615-53-9
1-(4-nitro-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone
